PLGA Nanoparticles with Cannabidiol for Efficient and Durable Antibacterial Applications

The Cannabidiol (CBD) are extensively used owing to their potent antibacterial effects. We developed CBD-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles using an emulsion process technology, resulting informing the PLGA@CBD nanoparticles. parameters were optimized three-dimensional surface plots. When scaled up under optimal conditions, corresponding loading content efficiency 16.51%. Compared with natural cannabidiol, physically modified PLGA became smooth, round, and solid, improving water solubility bioavailability, realizing long-time antibacterial. Therefore, showed better efficacy against Gram-positive bacteria. Our results confirm that have been achieved as long-acting delivery system, which improved treatment efficiency.